Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 616-14-8, is researched, SMILESS is CCC(CI)C, Molecular C5H11IJournal, Article, Chemical Science called Metal-free C(sp3)-H functionalization of sulfonamides via strain-release rearrangement, Author is Hu, Jiefeng; Yang, Xianyu; Shi, Shasha; Cheng, Bo; Luo, Xiaoling; Lan, Yu; Loh, Teck-Peng, the main research direction is unsaturated imine preparation diastereoselective chemoselective DFT; fluorotosylamide tosylbenzaldimine carbon hydrogen functionalization strain release rearrangement.Application of 616-14-8.
A metal-free reaction system that enables C-H bond functionalization of aliphatic sulfonamides R(CH2)2N(F)Ts (R = decyl, cyclohexyl, oxan-4-yl, benzyl, etc.) using DABCO as a promoter under mild conditions, affording a series of α,β-unsaturated imines R1CH=C(R)CH=NTs (R1 = Ph, 4-chlorophenyl, 2,3-dihydro-1-benzofuran-5-yl, etc.) in good yields with high selectivities was presented. This protocol tolerates a broad range of functionalities and can serve as a powerful synthetic tool for the late-stage modification of complex compounds More importantly, control experiments and detailed DFT calculations suggest that this process involves [2 + 2] cyclization/ring-cleavage reorganization, which opens up a new platform for the establishment of other related reorganization reactions.
When you point to this article, it is believed that you are also very interested in this compound(616-14-8)Application of 616-14-8 and due to space limitations, I can only present the most important information.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem