An article Synthesis of new heterocycle-based selenoamides as potent cytotoxic agents WOS:000607183100002 published article about CARBENE COMPLEXES; SELENIUM; CHROMIUM(0); TUNGSTEN(0); CHEMISTRY; SULFUR; AMIDES; MODEL in [Garcia-Lopez, J. G.; Terron, J. A.] IPN, CINVESTAV, Ctr Invest & Estudios Avanzados, Dept Farmacol, Av IPN, Gustavo A Madero 07360, Cd Mx, Mexico; [Gutierrez-Hernandez, A., I; Toscano, R. A.; Ramirez-Apan, M. T.; Lopez-Cortes, J. G.] Univ Nacl Autonoma Mexico, Inst Quim, Coyoacan 04510, Cd Mx, Mexico; [Ortega-Alfaro, M. C.] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Coyoacan 04510, Cd Mx, Mexico in 2021.0, Cited 45.0. Recommanded Product: 119-61-9. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9
We report the synthesis of a new series of aryl- and heteroaryl (hydroxy)ethyl selenoamides, in a two-step, one-pot sequence based on the aminolysis/selenative demetalation of Fischer ethoxycarbene complexes, in good to excellent global yields, as small cytotoxic molecules. The molecular structure of a 2-thienyl based selenoamide was confirmed by single-crystal X-Ray diffraction analysis. In vitro analysis against different human cancer (HCT-15, U251 and PC-3) and human T-lymphocyte (MT2) cell lines revealed that the 2-thienyl based selenoamide can be considered a potent and selective compound against the human prostatic adenocarcinoma (PC-3) cell line with an IC50 value of 14.5 mu M. [GRAPHICS]
About Benzophenone, If you have any questions, you can contact Garcia-Lopez, JG; Gutierrez-Hernandez, AI; Toscano, RA; Ramirez-Apan, MT; Terron, JA; Ortega-Alfaro, MC; Lopez-Cortes, JG or concate me.. Recommanded Product: 119-61-9
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