Recently I am researching about CROSS-COUPLING REACTIONS; IN-SITU GENERATION; METAL-FREE; CARBONYL-COMPOUNDS; CARBENE INSERTION; BOND FORMATION; 1,3-DIPOLAR CYCLOADDITION; STRAIGHTFORWARD SYNTHESIS; ALKENYLBORONIC ACIDS; ASYMMETRIC-SYNTHESIS, Saw an article supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); NSFCNational Natural Science Foundation of China (NSFC) [21971175, 21572148, 21973068]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ma, L; Jin, F; Cheng, X; Tao, SY; Jiang, GZ; Li, XX; Yang, JW; Bao, XG; Wan, XB. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde. Computed Properties of C7H5NO3
N-Tosylhydrazones have proven to be versatile synthons over the past several decades. However, to our knowledge, the construction of isoxazolines based on N-tosylhydrazones has not been examined. Herein, we report the first demonstrations of [2 + 2 + 1] cycloaddition reactions that allow the facile synthesis of isoxazolines, employing N-tosylhydrazones, tert-butyl nitrite (TBN) and alkenes as reactants. This process represents a new type of cycloaddition reaction with a distinct mechanism that does not involve the participation of nitrile oxides. This approach is both general and practical and exhibits a wide substrate scope, nearly universal functional group compatibility, tolerance of moisture and air, the potential for functionalization of complex bioactive molecules and is readily scaled up. Both control experiments and theoretical calculations indicate that this transformation proceeds via the in situ generation of a nitronate from the coupling of N-tosylhydrazone and TBN, followed by cycloaddition with an alkene and subsequent elimination of a tert-butyloxy group to give the desired isoxazoline.
Computed Properties of C7H5NO3. Bye, fridends, I hope you can learn more about C7H5NO3, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem