Day: January 18, 2022

I found the field of Chemistry very interesting. Saw the article Synthesis and biological evaluation of novel indoleamide derivatives as antioxidative and antitumor agents published in 2020. COA of Formula: C7H8N2O, Reprint Addresses Zhang, Z; Yan, MC (corresponding author), Jining Med Univ, Sch Pharm, 669 Xueyuan Rd, Rizhao 276800, Shandong, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Novel indole amide derivatives C1-C10 were successfully synthesized and characterized by H-1 NMR, C-13 NMR, IR, MS, and elemental analysis, and their molecular formulas were C14H10N6O, C13H10N4O, C16H13N3O2, C19H14N2O2, C16H11N3OS, C15H13N3O, C12H9N5O, C16H10ClN3OS, C15H17N3O2, and C13H14N2O3, respectively. The primary biological activities of these compounds were evaluated in vitro by the DPPH assay, H2O2-induced oxidative stress injury assay, and cytotoxicity assay. The results indicated that compounds C1, C2, C4, C7, and C9 exhibited DPPH center dot scavenging ability, while C3, C4, C5, and C8 showed potent growth-inhibitory activities against various human tumor cells, including MDA-MB-231, Hela, A549, and HT29. Interestingly, compound C4 showed potent scavenging effects on the DPPH radical and possessed protective effect on H2O2-induced oxidative stress injury in human neuroblastoma SH-SY5Y cells at low concentrations; however, C4 exhibited significant toxicity against four human tumor cells at a higher concentration in all treatments, and the range of IC50 value was 7.91 to 13.35 mu M.

Welcome to talk about 88-68-6, If you have any questions, you can contact Zhang, Z; Gu, YL; Wang, ZY; Wang, HN; Zhao, Y; Chu, XM; Zhang, CY; Yan, MC or send Email.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 2-Aminobenzamide. In 2021 J MOL STRUCT published article about FT-RAMAN; ACID in [Chortani, Sarra; Horchani, Mabrouk; Znati, Mansour; Ben Jannet, Hichem; Romdhane, Anis] Univ Monastir, Fac Sci Monastir, Chem Dept,Team Med Chem & Nat Prod LR11ES39, Lab Heterocycl Chem Nat Prod & React, Ave Environm, Monastir 5019, Tunisia; [Issaoui, Noureddine] Univ Monastir, Fac Sci Monastir, Phys Dept, Lab Quantum & Stat Phys LR18ES18, Ave Environm, Monastir 5019, Tunisia in 2021, Cited 37. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

New benzopyrimidinone derivatives have been synthesized by reaction of 2-aminobenzamide with different acyl chlorides in good yield and their structures were confirmed by H-1 NMR, C-13 NMR and mass spectrometry. The newly synthesized compounds were studied theoretically by Density Functional Theory (DFT) method with 6-311++G(d, p) basis set, structural and some spectroscopic parameters were determined. The synthesized compounds were assessed for their in vitro alpha-amylase inhibitory activity. The structure-activity relationship (SAR) was discussed with the help of molecular docking analysis. (C) 2021 ElsevierB.V. Allrightsreserved.

Application In Synthesis of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Chortani, S; Horchani, M; Znati, M; Issaoui, N; Ben Jannet, H; Romdhane, A or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about NSCLC; CHEMOTHERAPY; DOCETAXEL; SYSTEM, Saw an article supported by the . Published in ELSEVIER IRELAND LTD in CLARE ,Authors: Crino, L; Bronte, G; Bidoli, P; Cravero, P; Minenza, E; Cortesi, E; Garassino, MC; Proto, C; Cappuzzo, F; Grossi, F; Tonini, G; Sarobba, MG; Pinotti, G; Numico, G; Samaritani, R; Ciuffreda, L; Frassoldati, A; Bregni, M; Santo, A; Piantedosi, F; Illiano, A; De Marinis, F; Tamberi, S; Giannarelli, D; Delmonte, A. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea. SDS of cas: 64-10-8

Objectives: Brain metastases are common among patients with non-squamous non-small-cell lung cancer (NSCLC) and result in a poor prognosis. Consequently, such patients are often excluded from clinical trials. In Italy an expanded access program (EAP) was used to evaluate nivolumab efficacy and safety in this sub population outside a clinical trial. Materials and methods: In this EAP, nivolumab was available for patients with non-squamous NSCLC in progression after at least one systemic treatment for stage IIIB/IV disease. Nivolumab 3 mg/kg was administered intravenously every 2 weeks. Patients with brain metastases could be included if they were asymptomatic, neurologically stable and either off corticosteroids or on a stable or decreasing dose of <= 10 mg/day prednisone. Results: 409 out of 1588 patients included had asymptomatic or controlled brain metastases. A median of 7 doses (range 1-45) were delivered. Median follow-up was 6.1 months (range 0.1-21.9). The disease control rate was 39%: 4 patients had a complete response, 64 a partial response and 96 showed stable disease. At baseline, 118 patients were on corticosteroids and 74 were undergoing concomitant radiotherapy. The median overall survival in this subpopulation was 8.6 months (95% CI: 6.4-10.8). 337 discontinued treatment for various reasons, 23 (7%) of whom due to adverse events, in line with that observed in the overall population and in previous studies. Conclusions: Our results confirm that nivolumab is active in non-squamous NSCLC patients with brain metastases, despite their poor prognosis. Its safety profile is also concordant with results in the EAP overall population and in patients with other malignancies. SDS of cas: 64-10-8. Welcome to talk about 64-10-8, If you have any questions, you can contact Crino, L; Bronte, G; Bidoli, P; Cravero, P; Minenza, E; Cortesi, E; Garassino, MC; Proto, C; Cappuzzo, F; Grossi, F; Tonini, G; Sarobba, MG; Pinotti, G; Numico, G; Samaritani, R; Ciuffreda, L; Frassoldati, A; Bregni, M; Santo, A; Piantedosi, F; Illiano, A; De Marinis, F; Tamberi, S; Giannarelli, D; Delmonte, A or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. Authors Shibata, S; Masui, Y; Onaka, M in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Shibata, Shintaro; Masui, Yoichi] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538902, Japan; [Onaka, Makoto] Tokyo Univ Agr, Fac Life Sci, Setagaya Ku, 1-1-1 Sakuragaoka, Tokyo 1568502, Japan in 2021.0, Cited 47.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

We quantitatively synthesized N-unsubstituted (N-H) diphenylketimine from benzophenone and ammonia without solvent under ambient conditions on some solid acids, especially the proton-exchanged Y-type zeolite (H-Y), by a simple procedure. Similarly, other N-unsubstituted ketimines were also obtained in high yields by the reaction of alkyl aryl ketones or a dialkyl ketone having alpha-acidic hydrogens with a large excess of ammonia gas at 1 atm. without a solvent with the aid of the zeolite’s high dehydration ability and stabilization effects. (C) 2021 Elsevier Ltd. All rights reserved.

Category: thiomorpholine. Welcome to talk about 119-61-9, If you have any questions, you can contact Shibata, S; Masui, Y; Onaka, M or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Aalinejad, M; Pesyan, NN; Heidari, N; Batmani, H; Asl, AD in WILEY published article about FE3O4 NANOPARTICLES; EFFICIENT SYNTHESIS; 5-SUBSTITUTED TETRAZOLES; FACILE SYNTHESIS; ACID; NANOCATALYST; OXIDATION; COMPLEX; GLYCOL; GREEN in [Aalinejad, Michael; Pesyan, Nader Noroozi; Batmani, Hana; Asl, Aria Danandeh] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh 57159, Iran; [Heidari, Nosrat] Urmia Univ, Dept Phys Chem, Fac Chem, Orumiyeh 57159, Iran in 2019, Cited 46. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Ni@diaza crown ether complex supported on magnetic nanoparticle was provided by grafting technique. The catalytic activity of Fe3O4@diaza crown ether@Ni was explored through one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and it was used as an efficient and recoverably constant nanocatalyst. FT-IR, SEM, TEM, XRD, BET, ICP, EDS, and TGA techniques were employed to specify the nanocatalyst. This heterogeneous catalyst demonstrated acceptable recyclability and could be used again several times with no considerable loss of its catalytic activity.

HPLC of Formula: C7H8N2O. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020.0 DIABETES CARE published article about TYPE-2 DIABETES-MELLITUS; ADD-ON THERAPY; SGLT2 INHIBITORS; TOLERABILITY; METFORMIN in [Jabbour, Serge A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA; [Frias, Juan P.] Natl Res Inst, Los Angeles, CA USA; [Ahmed, Azazuddin] Apex Med Res, Chicago, IL USA; [Hardy, Elise] AstraZeneca, Gaithersburg, MD USA; [Choi, Jasmine] Statum Res, Irvine, CA USA; [Sjostrom, C. David] AstraZeneca, Gothenburg, Sweden; [Guja, Cristian] Carol Davila Univ Med & Pharm, Bucharest, Romania in 2020.0, Cited 17.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Recommanded Product: 64-10-8

OBJECTIVE In patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin produced greater reductions in glycemic parameters (glycated hemoglobin [HbA(1c)], fasting plasma glucose [FPG], and 2-h postprandial glucose [2-h PPG]), weight, and systolic blood pressure (SBP) than exenatide QW or dapagliflozin alone after 28 weeks of treatment in DURATION-8. Following a 24-week extension period, improvements were sustained at 52 weeks. In this study, we investigated efficacy and safety at 104 weeks after randomization. RESEARCH DESIGN AND METHODS DURATION-8 was a 104-week, multicenter, double-blind, randomized, active-controlled, phase 3 trial. In total, 695 adults (aged >= 18 years) with type 2 diabetes and inadequate glycemic control (HbA(1c)8.0-12.0% [64-108 mmol/mol]) despite stable metformin monotherapy (>= 1,500 mg/day) were randomly assigned (1:1:1) to receive exenatide 2 mg QW plus once-daily dapagliflozin 10 mg, exenatide QW plus placebo, or dapagliflozin plus placebo. All 104-week evaluations were exploratory. RESULTS At week 104, 431 (62.0%) patients completed treatment. The adjusted least squares mean change (SE) from baseline to week 104 in HbA(1c)was greater with exenatide QW plus dapagliflozin (-1.70% [0.11]) versus exenatide QW plus placebo (-1.29% [0.12];P= 0.007) and dapagliflozin plus placebo (-1.06% [0.12];P< 0.001). Clinically relevant changes in FPG, 2-h PPG, weight, and SBP were also observed with exenatide QW plus dapagliflozin. There were no unexpected safety findings, and exenatide QW plus dapagliflozin was well tolerated, with no episodes of major hypoglycemia. CONCLUSIONS In this exploratory analysis, among those individuals who completed the trial without rescue therapy, there was clinically relevant efficacy over 2 years with exenatide QW plus dapagliflozin, with no unexpected safety findings. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 64-10-8

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Vyas, KM; Mandal, P; Singh, R; Mobin, SM; Mukhopadhyay, S in [Vyas, Komal M.; Mandal, Poulami; Singh, Rinky; Mobin, Shaikh M.; Mukhopadhyay, Suman] Indian Inst Technol Indore, Sch Basic Sci, Discipline Chem, Khandwa Rd, Indore 453552, India; [Vyas, Komal M.] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India; [Mandal, Poulami] Helmholtz Zensrum Dresden Rossendorf, Dept Resource Ecol, D-01328 Dresden, Germany published Arene-ruthenium(II)-phosphine complexes: Green catalysts for hydration of nitriles under mild conditions in 2020, Cited 86. Quality Control of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Three new arene-ruthenium(II) complexes were prepared by treating [{RuCl(mu-Cl)(eta(6)-arene)}(2)] (eta(6)-arene = p-cymene) dimer with tri(2-furyl)phosphine (PFu(3)) and 1,3,5-triaza-7-phosphaadamantane (PTA), respectively to obtain [RuCl2(eta(6)-arene)PFu(3)] [Ru] -1, (RuCl(eta(6)-arene)(PFu(3))(PTA)]BF4 [Ru] -2 and HtuCl(eta(6)-arene)(PFu(3))(2)]BF4 [Ru] -3. All the complexes were structurally identified using analytical and spectroscopic methods including single-crystal X-ray studies. The effectiveness of resulting complexes as potential homogeneous catalysts for selective hydration of different nitriles into corresponding amides in aqueous medium and air atmosphere was explored. There was a remarkable difference in catalytic activity of the catalysts depending on the nature and number of phosphorus-donor ligands and sites available for catalysis. Experimental studies performed using structural analogues of efficient catalyst concluded a structural-activity relationship for the higher catalytic activity of [Ru] -1, being able to convert huge variety of aromatic, heteroaromatic and aliphatic nitriles. The use of eco-friendly water as a solvent, open atmosphere and avoidance of any organic solvent during the catalytic reactions prove the reported process to be truly green and sustainable.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Vyas, KM; Mandal, P; Singh, R; Mobin, SM; Mukhopadhyay, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Solid-State Membrane Sensors Based on Man-Tailored Biomimetic Receptors for Selective Recognition of Isoproturon and Diuron Herbicides WOS:000585117700001 published article about MOLECULARLY IMPRINTED POLYMERS; PHASE EXTRACTION; POTENTIAL STABILITY; CONDUCTING POLYMERS; CONTROLLED-RELEASE; ELECTRODES; PESTICIDES; SAMPLES in [Kamel, Ayman H.] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt; [Amr, Abd El-Galil E.; Al-Omar, Mohamed A.; Almehizia, Abdulrahman A.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia; [Amr, Abd El-Galil E.] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt in 2020.0, Cited 51.0. Recommanded Product: 64-10-8. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Solid-contact ion-selective electrodes (SC-ISEs) have shown great potential for routine and portable ion detection. The introduction of nanomaterials as ion-to-electron transducers and the adoption of different performance-enhancement strategies have significantly promoted the development of SC-ISEs. Herein, new solid-contact ion-selective electrodes, along with the implementation of multiwalled carbon nanotubes (MWCNTs) as ion-to-electron transducers and potassium tetrakis (p-chlorophenyl) borate (KTpClB) as lipophilic ionic additives, were presented for the detection of isoproturon (IPU) and diuron (DU) herbicides. Molecularly imprinted polymers (MIPs), with special molecule recognition properties for isoproturon (IPU) and diuron (DU), were prepared, characterized, and introduced as sensory recognition materials in the presented electrodes. Sensors revealed a near-Nernstian response for both isoproturon (IPU) and diuron (DU) with slopes of 53.1 +/- 1.2 (r(2) = 0.997) and 57.2 +/- 0.3 (r(2) = 0.998) over the linear ranges of 2.2 x 10(-6)-1.0 x 10(-3) M and 3.2 x 10(-6)-1.0 x 10(-3) M with detection limits of 8.3 x 10(-7) and 1.4 x 10(-6) M, respectively. The response time of the presented sensors was found to be <5 s and the lifetime was at least eight weeks. The sensors exhibited good selectivity towards isoproturon (IPU) and diuron (DU) in comparison with some other herbicides, alkali, alkaline earth, and heavy metal ions. The presented sensors were successfully applied for the direct determination of isoproturon (IPU) and diuron (DU) in real water samples. Recommanded Product: 64-10-8. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Heriyanto; Pahlevani, F; Sahajwalla, V in ELSEVIER SCI LTD published article about in [Heriyanto; Pahlevani, Farshid; Sahajwalla, Veena] UNSW, Sch Mat Sci & Engn, Ctr Sustainable Mat Res & Technol SMaRT, Sydney, NSW 2052, Australia in 2019.0, Cited 24.0. Quality Control of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

This study reports an innovative pathway for successfully synthesizing composite panels using various waste input. For this purpose, seven types of powder from waste or widely available filler i.e. Quartz off-cut, sand, waste seashell, dolomite, limestone aggregates, concrete waste and limestone dust were used. The study aims to assess the effectiveness and mechanical properties of the various waste powder in the production of powder-resin composites. The panels were then compared with the novel polymeric glass composite (PGC) in the previous study (Heriyanto et al., 2018). Following the same procedure in PGC, the filler was individually grounded to 64-108 mu m and chemically treated with amino silane coupling agent (CA). The powder filler (untreated or treated) is then mixed with the resin binder with a ratio of 80/20 respectively, followed by hot pressing the mixture at the pressure of 550 bar at 65 degrees C for 1 h. The final composite slab is then further cut for mechanical testing. It was found in the study that when CA was not added, surface roughness of the powder particles affected the flexural strength of the final panel significantly. High surface roughness particles such as in Quartz, sand and seashell adhere effectively with the resin binder which led to higher strength. On the contrary, other factors like smooth particle morphology in glass, dolomite and limestone as well as porous structure in concrete and clump of very fine powder in limestone dust degrade the strength of the final panels. With CA addition, adhesion between resin and powder filler were improved significantly. Flexural strength after the CA treatment was found to be much affected by particle characteristics. Silica-based panels i.e. quartz, sand and glass which consist of high strength and hardness of silica particles perform better compared to that of calcium carbonate-based panels. Compression strength, toughness, stiffness, scratch resistance, density and water absorption were also reported in this study. The properties of all the treated panels are found to be comparable, or if not, much better than natural stones. These new approaches of using waste filler in powder – resin based composites can be a new alternative to produce green materials that deliver economic and environmental benefits. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 1-Phenylurea. Welcome to talk about 64-10-8, If you have any questions, you can contact Heriyanto; Pahlevani, F; Sahajwalla, V or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Chromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study WOS:000470939200050 published article about ASYMMETRIC TRANSFER HYDROGENATION; CROSS-COUPLING REACTIONS; ENANTIOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; HOMOGENEOUS HYDROGENATION; GRIGNARD-REAGENTS; IRON; COMPLEXES; ARENES; ARYL in [Han, Bo; Zeng, Xiaoming] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Shaanxi, Peoples R China; [Zeng, Xiaoming] Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China; [Ma, Pengchen; Chen, Hui] Chinese Acad Sci, BNLMS, CAS Key Lab Photochem, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China; [Han, Bo] Yanan Univ, Coll Chem & Chem Engn, Shaanxi Key Lab Chem React Engn, Yanan 716000, Peoples R China; [Cong, Xuefeng] Northeast Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China in 2019, Cited 93. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Quality Control of Anthrone

Polycyclic aromatic hydrocarbons are difficult substrates for hydrogenation because of the thermodynamic stability caused by aromaticity. We report here the first chromium- and cobalt-catalyzed, regiocontrolled hydrogenation of polycyclic aromatic hydrocarbons at ambient temperature. These reactions were promoted by low-cost chromium or cobalt salts combined with diimino/carbene ligand and methylmagnesium bromide and are characterized by high regioselectivity and expanded substrate scope that includes tetracene, tetraphene, pentacene, and perylene, which have rarely been reduced. The approach provides a cost-effective catalytic protocol for hydrogenation, is scalable, and can be utilized in the synthesis of tetrabromo- and carboxyl-substituted motifs through functionalization of the hydrogenation product. The systematic theoretical mechanistic modelings suggest that low-valent Cr and Co monohydride species, most likely from zerovalent transition metals, are capable of mediating these hydrogenations of fused PAHs.

Quality Control of Anthrone. Welcome to talk about 90-44-8, If you have any questions, you can contact Han, B; Ma, PC; Cong, XF; Chen, H; Zeng, XM or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem