I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Quinazoline-4(3H)-one derivatives as novel and potent inhibitors of soluble epoxide hydrolase: Design, synthesis and biological evaluation published in 2020. Computed Properties of C7H8N2O, Reprint Addresses Tabatabai, SA (corresponding author), Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
Inhibition of soluble epoxide hydrolase (sEH) is considered as a promising target to reduce blood pressure, improve insulin sensitivity, and decrease inflammation. In this study, a series of some novel quinazoline-4(3H)one derivatives (3a-t) with varying steric and electronic properties was designed, synthesized and evaluated as sEH Inhibitors. Most of the synthesized compounds had similar inhibitory activity to the commercial reference inhibitor, 12-(3-adamantan-1-ylureido)dodecanoic acid, and amongst them, 4-chloro-N-(4-(4-oxo-3,4-dihydroquinazoline-2-yl)phenyl)benzamide (3g) was identified as the most active sEH inhibitor (IC50 = 0.5 nM), about 2-fold more potent compared to the reference inhibitor. The results of molecular modeling followed by biological studies indicate that a quinazolinone ring serves as a suitable scaffold to develop novel small molecule candidates to inhibit sEH and the nature of substituent on the amide moiety has a moderate effect on the activity.
About 2-Aminobenzamide, If you have any questions, you can contact Hejazi, L; Rezaee, E; Tabatabai, SA or concate me.. Computed Properties of C7H8N2O
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem