Computed Properties of C10H12O3. I found the field of Chemistry very interesting. Saw the article F-19-and(18)F-arene deoxyfluorination via organic photoredox-catalysed polarity-reversed nucleophilic aromatic substitution published in 2020, Reprint Addresses Nicewicz, DA (corresponding author), Univ N Carolina, Dept Chem, Venable Labs, Chapel Hill, NC 27515 USA.; Li, ZB (corresponding author), Univ N Carolina, Dept Radiol, Biomed Res Imaging Ctr, Chapel Hill, NC 27515 USA.; Li, ZB (corresponding author), Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA.. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate.
Nucleophilic aromatic substitution (SNAr) is routinely used to install (19)F(-)and (18)F(-)in aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. Here we demonstrate that a polarity-reversed photoredox-catalysed arene deoxyfluorination that operates via cation-radical-accelerated SNAr enables the fluorination of electron-rich arenes with (19)F(-)and (18)F(-)under mild conditions, and thus complements the traditional arene polarity requirements necessary for SNAr-based fluorination. The utility of our radiofluorination strategy is highlighted by short reaction times, compatibility with multiple nucleofuges and high radiofluorination yields, especially that of an important cancer positron emission tomography agent [F-18]5-fluorouracil. Taken together, our fluorination approach enables the development of fluorinated and radiofluorinated compounds that can be difficult to access by classical SNAr strategies, with the potential for use in the synthesis and discovery of positron emission tomography radiopharmaceuticals.
Computed Properties of C10H12O3. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Tay, NES; Chen, W; Levens, A; Pistritto, VA; Huang, Z; Wu, ZH; Li, ZB; Nicewicz, DA or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem