Day: October 19, 2021

Quality Control of 2-Aminobenzamide. In 2021 NEW J CHEM published article about ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; COUPLING REACTIONS; GRIGNARD-REAGENTS; QUINOLINE; DERIVATIVES; SULFUR; THIOETHERS; ALKALOIDS; CHEMISTRY in [Hu, Fang-Peng; Zhang, Ming-Ming; Huang, Guo-Sheng] Lanzhou Univ, Dept Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2021, Cited 55. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A Lewis-acid-promoted cyclization reaction of benzoyl chlorides with 2-(4,5-dihydrooxazol-2-yl)anilines, which can offer a series of N3-chloroethyl quinazolinones, is disclosed. The reaction is compatible with the functional groups of the substrates; environment-friendly AlCl3 is probably the chloride source. Moreover, the addition of NH4SCN can also produce a range of N3-thiocyanatoethyl quinazolinones in moderate-to-good yields.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Hu, FP; Zhang, MM; Huang, GS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 99-61-6. In 2021 J MOL STRUCT published article about METAL-ORGANIC-FRAMEWORK; GRAPHENE OXIDE COMPOSITES; MULTICOMPONENT REACTIONS; DRUG-DELIVERY; ADSORPTION; EFFICIENT; DEGRADATION; PERFORMANCE; DERIVATIVES; PRODUCTS in [Bakhshali-Dehkordi, Raziyeh; Ghasemzadeh, Mohammad Ali] Islamic Azad Univ, Qom Branch, Dept Chem, Qom, Iran in 2021, Cited 77. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

Zeolitic imidazolate frameworks (prototype system ZIF-8) supported on the Fe3O4@TiO2@ILs magnetic nanostructure (Fe3O4@TiO2@ILs-ZIF-8) was first synthesized and it showed high catalytic activity for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives. The multi-component reactions of various aldehydes, 2-aminobenzimidazole and ethyl acetoacetate were efficiently catalyzed using a novel magnetic nanocatalyst at room temperature. The nanocatalyst was easily separated from the reaction media by an external magnet and its catalytic behavior was remained significantly after six runs. The catalyst was fully characterized by FT-IR, SEM, TGA, XRD, EDX, TEM, and VSM analyses. The present methodology offers various advantages such as, excellent yields, simple procedures, short reaction times, simple workup and mild reaction conditions. (C) 2021 Elsevier B.V. All rights reserved.

SDS of cas: 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Bakhshali-Dehkordi, R; Ghasemzadeh, MA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition WOS:000523577000001 published article about DERIVATIVES; FLAVONES; TUBULIN; DESIGN; ARREST in [Thorat, Nitin M.; Thopate, Shankar R.] Ahmednagar Coll, Prof John Barnabas Post Grad Sch Biol Studies, Dept Chem, Stn Rd, Ahmednagar 414001, Maharashtra, India; [Thorat, Nitin M.] Maharaja Jivajirao Shinde Arts Sci Commerce Coll, Dept Chem, Shrigonda 413701, Maharashtra, India; [Sarkate, Aniket P.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India; [Lokwani, Deepak K.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur 425405, Maharashtra, India; [Tiwari, Shailee V.] Durgamata Inst Pharm, Dept Pharmaceut Chem, Parbhani 431401, Maharashtra, India; [Azad, Rajaram] Univ Hyderabad, Dept Anim Biol, Hyderabad 500046, India; [Thopate, Shankar R.] Shri Sadguru Gangageer Maharaj Sci Gautam Arts &, Dept Chem, Ahmednagar 423601, Maharashtra, India in 2021.0, Cited 31.0. Recommanded Product: 99-61-6. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Series of novel N-benzyl derivatives of 6-aminoflavone (9a-n) were synthesized and evaluated for anticancer and topoisomerase II enzyme inhibition activity. All the synthesized compounds were screened for in vitro anticancer activity against human breast cancer cell line (MCF-7) and human lung cancer cell line (A-549). Among the synthesized compounds, 9f and 9g were found to be the most potent anticancer agents against human breast cancer cell line (MCF-7) with IC50 values of 9.35 mu M and 9.58 mu M, respectively. Compounds 9b, 9c and 9n exhibited promising anticancer activity against human lung cancer cell line (A-549) with 43.71%, 46.48% and 44.26% inhibition at the highest concentration of 10 mu M, respectively. Compounds 9c, 9f and 9g have ability to inhibit the topoisomerase II enzyme. Compound 9f showed most potent topoisomerase II enzyme inhibition activity with IC50 value of 12.11 mu M. Further, these compounds have a high potential to be developed as a promising topoisomerase II inhibitors.

Recommanded Product: 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Thorat, NM; Sarkate, AP; Lokwani, DK; Tiwari, SV; Azad, R; Thopate, SR or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 CHEM SCI published article about 1,4-DIBORATION; BORYL in [Suzuki, Akane; Yamashita, Makoto] Nagoya Univ, Grad Sch Engn, Dept Mol & Macromol Chem, Chikusa Ku, Nagoya, Aichi 4648603, Japan; [Guo, Xueying; Lin, Zhenyang] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Clear Water Bay, Hong Kong, Peoples R China in 2021.0, Cited 128.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. COA of Formula: C13H10O

A di(o-tolyl)borylgold complex was synthesized via the metathesis reaction of a gold alkoxide with tetra(o-tolyl)diborane(4). The resulting diarylborylgold complex exhibited a Lewis acidic boron center and a characteristic visible absorption that arises from its HOMO-LUMO excitation, which is narrower than that of a previously reported dioxyborylgold complex. The diarylborylgold complex reacted with isocyanide in a stepwise fashion to afford single- and double-insertion products and a C-C coupled product. Reactions of this diarylborylgold complex with C = O/N double bond species furnished addition products under concomitant formation of Au-C and B-O/N bonds, which suggests nucleophilic reactivity of the gold metal center. DFT calculations provided details of the underlying reaction mechanism, which involves an initial coordination of the C = O/N bond to the boron vacant p-orbital of the diarylboryl ligand followed by a migration of the gold atom from the tetracoordinate sp(3)-hybridized boron center, which is analogous to the reactivity of the conventional sp(3)-hybridized borate species. The DFT calculations also suggested a stepwise mechanism for the reaction of this diarylborylgold complex with isocyanide, which afforded three different reaction products depending on the applied reaction conditions.

COA of Formula: C13H10O. About Benzophenone, If you have any questions, you can contact Suzuki, A; Guo, XY; Lin, ZY; Yamashita, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Framework Copper Catalyzed Oxidative Synthesis of Quinazolinones: A Benign Approach Using Cu-3(BTC)(2)MOF as an Efficient and Reusable Catalyst WOS:000563958600020 published article about METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; TERMINAL ALKYNES; TANDEM SYNTHESIS; 2-AMINOBENZAMIDES; COMPOSITE; AMINATION; CHEMISTRY; ACIDS in [Latha, Ganesapandian; Devarajan, Nainamalai; Suresh, Palaniswamy] Madurai Kamaraj Univ, Sch Chem, Dept Nat Prod Chem, Supramol & Catalysis Lab, Madurai 625021, Tamil Nadu, India in 2020, Cited 60. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Product Details of 88-68-6

A benign and straightforward method to access quinazolinones have been developed using easily preparable Cu-3(BTC)(2)MOF as a sustainable solid-Lewis acid catalyst under mild condition. Cu-3(BTC)(2)MOF was prepared and characterized using various analytical tools such as PXRD, FT-IR, SEM, TGA, and ICP-OES. Synthesis of the quinazolinone is catalyzed by the presence of coordinatively unsaturated open Cu(II)sites in Cu-3(BTC)(2)MOF using renewable ethanol as a solvent with minimum copper loading (0.07 mmol) without any harsh reaction condition. A series of substituted quinazolinones were synthesized with good to excellent yields. The efficiency of the present framework copper catalysts was rationalized by comparing with other MOFs and homogeneous catalytic systems. The stability of the catalyst was demonstrated by six consecutive runs and heterogeneity test, which was also evidenced from the technical supports such as PXRD, FT-IR and SEM analyses of the recovered catalyst.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Latha, G; Devarajan, N; Suresh, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Gilan, MM; Khazaei, A; Sarmasti, N in SPRINGER published article about in [Gilan, Maryam Mahmoudiani; Khazaei, Ardeshir; Sarmasti, Negin] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Hamadan, Iran in 2021.0, Cited 51.0. Application In Synthesis of 3-Nitrobenzaldehyde. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Eggshell as a solid waste was loaded on a nano-Fe3O4 surface. Then, in one step, it (Fe3O4@eggshell) was converted to Fe3O4@Ca-3(PO4)(2) as a nano-magnetic, green, cheap, and environmentally friendly catalyst. Techniques such as FT-IR, VSM, FESEM, TEM, EDX, XRD, and TGA were used to characterize the as-synthesized catalyst. The catalytic activity of Fe3O4@Ca-3(PO4)(2) was evaluated in the synthesis of 1,2,4,5-tetra-substituted imidazole derivatives through a one-pot multicomponent reaction. The design of the experiment as a systematic statistical approach was used to obtain the optimum point of the reaction condition so that 0.05 g of the as-synthesized catalyst and 94.77 degrees C were the best condition (which provides 90% yield for the benchmark reaction). Then, 1,2,4,5-tetra-substituted imidazole derivatives in the optimum condition were synthesized with very low reaction times in good yields. The as-prepared catalyst was retrieved through a magnet and used several times without significant loss of catalytic activity.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Gilan, MM; Khazaei, A; Sarmasti, N or concate me.. Application In Synthesis of 3-Nitrobenzaldehyde

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Waste-Minimized Cyanosilylation of Carbonyls Using Fluoride on Polymeric Ionic Tags in Batch and under Continuous Flow Conditions WOS:000644738000026 published article about METAL-ORGANIC FRAMEWORKS; SELECTIVE ALDEHYDE CYANOSILYLATION; SOLVENT-FREE CYANOSILYLATION; LEWIS-BASE ACTIVATION; ENANTIOSELECTIVE CYANOSILYLATION; KNOEVENAGEL CONDENSATION; TRIMETHYLSILYL CYANIDE; EFFICIENT SYNTHESIS; CHEMICAL-REACTIONS; BETA-AZIDATION in [Ferlin, Francesco; Valentini, Federica; Brufani, Giulia; Vaccaro, Luigi] Univ Perugia, Lab Green SOC, Dipartimento Chim Biol & Biotecnol, I-06123 Perugia, Italy; [Lanari, Daniela] Univ Perugia, Dipartimento Sci Farmaceut, I-06123 Perugia, Italy in 2021.0, Cited 82.0. Safety of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Herein, we report the development of a tailor-made fluoride-based heterogeneous catalyst, POLITAG-F, for the waste-minimized continuous production of cyanohydrin silyl ethers. The careful designing of the polymeric support and the choice of fluoride ion as the anionic species resulted in the improvement of catalytic efficiency and allowed the effective conversion of different carbonyls (aldehydes, ketones, and unsaturated ketones). The POLITAG-F catalyst, employed under flow conditions, led to the conversion of large amounts (over 100 mmol) of the substrate with a productivity of 0.1 mmol min(-1). In addition, flow conditions allowed to minimize the waste production reaching an associated E-factor value of 0.04. An exhaustive evaluation of the environmental impact of our protocol has been reported by considering several green metrics (process mass intensity, atom economy, and reaction mass efficiency) and also the benign index and the safety hazard index of the process.

About Benzophenone, If you have any questions, you can contact Ferlin, F; Valentini, F; Brufani, G; Lanari, D; Vaccaro, L or concate me.. Safety of Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 1-Phenylurea. In 2019.0 MOL CANCER THER published article about ACQUIRED-RESISTANCE; CAPRI-GOIM; PLUS CETUXIMAB; INHIBITOR; MUTATIONS in [Martini, Giulia; Cardone, Claudia; Vitiello, Pietro Paolo; Belli, Valentina; Napolitano, Stefania; Troiani, Teresa; Ciardiello, Davide; Della Corte, Carminia Maria; Morgillo, Floriana; Matrone, Nunzia; Ciardiello, Fortunato; Martinelli, Erika] Univ Campania L Vanvitelli, Med Oncol, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy; [Sforza, Vincenzo] Fdn Pascale, IRCCS, Ist Nazl Tumori, Dept Clin Expt Thorac Oncol, Naples, Italy; [Papaccio, Gianpaolo; Desiderio, Vincenzo; Tirino, Virginia] Univ Campania Luigi Vanvitelli Napoli, Dept Expt Med, Naples, Italy; [Paul, Mariel C.; Moreno-Viedma, Veronica; Sibilia, Maria] Med Univ Vienna, Comprehens Canc Ctr, Dept Med 1, Inst Canc Res, Borschkegasse 8a, Vienna, Austria; [Normanno, Nicola; Rachiglio, Anna Maria] Fdn Pascale, IRCCS, Ist Nazl Tumori, Cell Biol & Biotherapy Unit, Naples, Italy; [Maiello, Evaristo; Latiano, Tiziana Pia; Rizzi, Daniele] Hosp Casa Sollievo Della Sofferenza San Giovanni, Med Oncol, San Giovanni Rotondo, Italy; [Signoriello, Giuseppe] Univ Campania L Vanvitelli, Biostat, Dipartimento Salute Mentale & Fis & Med Prevent, Naples, Italy in 2019.0, Cited 24.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

The EPHA2 tyrosine kinase receptor is implicated in tumor progression and targeted therapies resistance. We evaluated EPHA2 as a potential resistance marker to the antiepidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in colorectal cancer. We studied activation of EPHA2 in a panel of human colorectal cancer cell lines sensitive or resistant to anti-EGFR drugs. The in vitro and in vivo effects of ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab treatment were tested. Fonnalin-fixed paraffin-embedded tumor specimens from 82 RAS wild-type (WV) metastatic colorectal cancer patients treated with FOLFIRI + cetuximab as first-line therapy in the CAPRI-COIM trial were assessed for EPHA2 expression by immunohistochemistry and correlated with treatment efficacy. EPHA2 was differentially activated in colorectal cancer cell lines. Combined treatment with ALW-II-41-27 plus cetuximab reverted primary and acquired resistance to cetuximab, causing cell growth inhibition, inducing apoptosis and cell-cycle G1-G2 arrest. In tumor xenograft models, upon progression to cetuximab, ALW-II-41-27 addition significantly inhibited tumor growth. EPHA2 protein expression was detected in 55 of 82 tumor samples, frequently expressed in less-differentiated and left-sided tumors. High levels of EPHA2 significantly correlated with worse progression-free survival [8.6 months; confidence interval (CI) 95%, 6.4-10.8; vs. 12.3 months; CI 95%, 10.4-14,2; P = 0.03] and with increased progression rate (29% vs. 9%, P = 0.02). A specific EPHA2 inhibitor reverts in vitro and in vivo primary and acquired resistance to anti-ECFR therapy. EPHA2 levels are significantly associated with worse outcome in patients treated with FOLFIRI + cetuximab. These results highlight EPHA2 as a potential therapeutic target in metastatic colorectal cancer.

About 1-Phenylurea, If you have any questions, you can contact Martini, G; Cardone, C; Vitiello, PP; Belli, V; Napolitano, S; Troiani, T; Ciardiello, D; Della Corte, CM; Morgillo, F; Matrone, N; Sforza, V; Papaccio, G; Desiderio, V; Paul, MC; Moreno-Viedma, V; Normanno, N; Rachiglio, AM; Tirino, V; Maiello, E; Latiano, TP; Rizzi, D; Signoriello, G; Sibilia, M; Ciardiello, F; Martinelli, E or concate me.. Application In Synthesis of 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021 ORG LETT published article about CATALYZED INTERMOLECULAR HYDROAMINATION; ALKENES; AMIDES; CYCLIZATION; RADICALS; OLEFINS; ALKYNES in [Ayushee; Meena, Priyanka; Verma, Akhilesh K.] Univ Delhi, Dept Chem, Delhi 110007, India; [Patel, Monika; Verma, Akhilesh K.] Univ Delhi, Ramjas Coll, Dept Chem, Delhi 110007, India; [Jahan, Kousar; Bharatam, Prasad, V; Verma, Akhilesh K.] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Mohali 160062, Punjab, India in 2021, Cited 48. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Ayushee; Patel, M; Meena, P; Jahan, K; Bharatam, PV; Verma, AK or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 90-44-8. In 2019 PHYTOMEDICINE published article about LEAF GEL EXTRACT; IN-VITRO; OXIDATIVE STRESS; ANTIINFLAMMATORY ACTIVITY; INHIBITS PROLIFERATION; BARBADENSIS MILLER; MOLECULAR-WEIGHT; EMODIN; SKIN; ANTIOXIDANT in [Kumar, Ramesh; Singh, Amit Kumar; Gupta, Ashutosh; Pandey, Abhay K.] Univ Allahabad, Dept Biochem, Allahabad 211002, Uttar Pradesh, India; [Bishayee, Anupam] Lake Erie Coll Osteopath Med, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA in 2019, Cited 145. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Background: Aloe vera is commonly used in the primary health care of human beings since time immemorial. It is an herb widely used in various traditional systems of medicine worldwide. Systematic and scientific investigation on A. vera as a medicinal plant has drawn considerable attention, and many laboratories are involved in isolation, characterization and evaluation of phytoconstituents for their nutraceutical and pharmaceutical applications. Purpose: The aim of this study was to provide an overview of the phytochemical, biological and medicinal attributes of A. vera against various diseases with special emphasis on underlying mechanisms of action. Methods: PubMed, EBOSCO host, Science Direct, Scopus, and Cochrane library databases were utilized to search literature published between1977 and 2019 (fill March). Major keywords used in various combinations included: Aloe vera, phytochemistry, metabolism, pharmacological activity, prevention, treatment, health, disease, in vivo, in vitro, and clinical studies. Results: Various biological and pharmacological activities of A. vera, such as antioxidant, anti-inflammatory, immuno-modulatory, antimicrobial, antiviral, antidiabetic, hepatoprotective, anticancer, and skin-protective and wound-healing responses, have been attributed to the presence of many active compounds, including anthraquinones, anthrones, chromones, flavonoids, amino acids, lipids, carbohydrates, vitamins and minerals. Conclusion: Based on various preclinical studies, A. vera constituents have enormous potential to prevent and treat various diseases. Randomized clinical trials are needed to understand the full therapeutic potential of this unique medicinal plant.

SDS of cas: 90-44-8. About Anthrone, If you have any questions, you can contact Kumar, R; Singh, AK; Gupta, A; Bishayee, A; Pandey, AK or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem