Day: October 18, 2021

An article Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia WOS:000471834500012 published article about ANDROGEN RECEPTOR; HISTONE H3; COACTIVATOR; CARM1; METHYLATION; DISCOVERY; TRANSCRIPTION; EXPRESSION in [Guo, Zuhao; Cao, Danyan; Chen, Danqi; Wang, Qi; Li, Yanlian; Li, Jian; Du, Zhiyan; Wang, Xin; Chen, Lin; Shen, Jingkang; Xiong, Bing] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Zhang, Zhuqing; Yang, Hong; Xu, Xiaowei; Zheng, Xineng; Ding, Jian; Geng, Meiyu; Huang, Xun] Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Zhang, Zhuqing; Xu, Xiaowei; Zheng, Xineng; Wang, Qi; Ding, Jian; Geng, Meiyu; Huang, Xun; Xiong, Bing] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China in 2019.0, Cited 46.0. SDS of cas: 64-10-8. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression of PRMT4 has been found to be involved in several types of cancers. Selective and in vivo effective PRMT4 inhibitors are needed for demonstrating PRMT4 as a promising therapeutic target. On the basis of compound 6, a weak dual PRMT4/6 inhibitor, we constructed a tetrahydroisoquinoline scaffold through a cut-and-sew scaffold hopping strategy. The subsequent SAR optimization efforts employed structure-based approach led to the identification of a novel PRMT4 inhibitor 49. Compound 49 exhibited prominently high potency and selectivity, moderate pharmacokinetic profiles, and good antitumor efficacy in acute myeloid leukemia xenograft model via oral administration, thus demonstrating this compound as a useful pharmacological tool for further target validation and drug development in cancer therapy.

SDS of cas: 64-10-8. About 1-Phenylurea, If you have any questions, you can contact Guo, ZH; Zhang, ZQ; Yang, H; Cao, DY; Xu, XW; Zheng, XN; Chen, DQ; Wang, Q; Li, YL; Li, J; Du, ZY; Wang, X; Chen, L; Ding, J; Shen, JK; Geng, MY; Huang, X; Xiong, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Stoichiometric Formation of an Oxoiron(IV) Complex by a Soluble Methane Monooxygenase Type Activation of O-2 at an Iron(II)-Cyclam Center published in 2020. Recommanded Product: Anthrone, Reprint Addresses Ray, K (corresponding author), Humboldt Univ, Inst Chem, D-12489 Berlin, Germany.. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

In soluble methane monooxygenase enzymes (sMMO), dioxygen (O-2) is activated at a diiron(II) center to form an oxodiiron(IV) intermediate Q that performs the challenging oxidation of methane to methanol. An analogous mechanism of O-2 activation at mono- or dinuclear iron centers is rare in the synthetic chemistry. Herein, we report a mononuclear non-heme iron(II)cyclam complex, 1-trans, that activates O-2 to form the corresponding iron(IV)-oxo complex, 2-trans, via a mechanism reminiscent of the O-2 activation process in sMMO. The conversion of 1-trans to 2-trans proceeds via the intermediate formation of an iron(III)-superoxide species 3, which could be trapped and spectroscopically characterized at -50 degrees C. Surprisingly, 3 is a stronger oxygen atom transfer (OAT) agent than 2-trans; 3 performs OAT to 1-trans or PPh 3 to yield 2-trans quantitatively. Furthermore, 2-trans oxidizes the aromatic C-H bonds of 2,6-di-tert-butylphenol, which, together with the strong OAT ability of 3, represents new domains of oxoiron(IV) and superoxoiron(III) reactivities.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. In 2019 ORG LETT published article about OXIDATIVE SYNTHESIS; O-AMINOBENZAMIDES; QUINAZOLIN-4(3H)-ONES; DOXAZOSIN; ALCOHOLS in [Arachchige, Pandula T. Kirinde; Yi, Chae S.] Marquette Univ, Dept Chem, Milwaukee, WI 53201 USA in 2019, Cited 45. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Arachchige, PTK; Yi, CS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of Benzophenone. In 2021.0 J ORG CHEM published article about DOPED GRAPHENE; FUNCTIONALIZATION; MULTIPLE; ELECTROCATALYSTS; TRANSISTORS; ANNULATION; CLEAVAGE; CASCADE in [Biswal, Pragati; Banjare, Shyam Kumar; Pati, Bedadyuti Vedvyas; Mohanty, Smruti Ranjan; Ravikumar, Ponneri Chandrababu] HBNI, Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, Khurja 752050, Odisha, India in 2021.0, Cited 44.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

A Rh-catalyzed pot and step economic synthesis of aza-polycyclic aromatic hydrocarbons (N-PAHs) from readily available aryl ketones and alkynes has been disclosed. Additionally, a novel synthetic application of the well-known aminating reagent hydroxylamine-O-sulfonic acid (HOSA) has been explored as an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline. Multiple bond formation in a single operation through a cascade of triple C-H bond activations is the beauty of this protocol. The challenging annulations of two different alkynes in a regioselective fashion have been demonstrated effectively. Mechanistic studies reveal that 3,4-diphenyl-1-methylisoquinoline is an active intermediate for this one-pot transformation.

Safety of Benzophenone. About Benzophenone, If you have any questions, you can contact Biswal, P; Banjare, SK; Pati, BV; Mohanty, SR; Ravikumar, PC or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 90-44-8. Recently I am researching about INDUCE APOPTOSIS; PHOTOCHEMICAL ISOMERIZATION; TRICYCLIC ANTIDEPRESSANTS; CELL-PROLIFERATION; ADULT BURKITT; NITROSTYRENE; DEAMINATION; DERIVATIVES; ACTIVATION; LEUKEMIA, Saw an article supported by the Trinity College Dublin. Published in MDPI in BASEL ,Authors: Byrne, AJ; Bright, SA; McKeown, JP; O’Brien, JE; Twamley, B; Fayne, D; Williams, DC; Meegan, MJ. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminary studies on the antiproliferative activity of a library of 9,10-dihydro-9,10-ethanoanthracene based compounds structurally related to the antidepressant drug maprotiline against BL cell lines MUTU-1 and DG-75. Structural modifications were achieved by Diels-Alder reaction of the core 9-(2-nitrovinyl)anthracene with number of dienophiles including maleic anhydride, maleimides, acrylonitrile and benzyne. The antiproliferative activity of these compounds was evaluated in BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant). The most potent compounds 13j, 15, 16a, 16b, 16c, 16d and 19a displayed IC50 values in the range 0.17-0.38 mu M against the BL cell line EBV- MUTU-1 and IC50 values in the range 0.45-0.78 mu M against the chemoresistant BL cell line EBV+ DG-75. Compounds 15, 16b and 16c demonstrated potent ROS dependent apoptotic effects on the BL cell lines which were superior to the control drug taxol and showed minimal cytotoxicity to peripheral blood mononuclear cells (PBMCs). The results suggest that this class of compounds merits further investigation as antiproliferative agents for BL.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Kargar, S; Elhamifar, D; Zarnegaryan, A in ELSEVIER published article about in [Kargar, Shiva; Elhamifar, Dawood; Zarnegaryan, Ali] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2021, Cited 83. SDS of cas: 99-61-6. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A novel ionic liquid modified graphene oxide supported Mo-complex [GO@IL/MoO2(acae)(2)] was successfully prepared, characterized and its catalytic application was investigated. The GO@IL/MoO2(acae)(2) catalyst was prepared through the surface modification of graphene oxide with alkyl imidazolium chloride followed by treatment with molybdenyl acetylacetonate. The GO@IL/MoO2(acae)(2) catalyst was characterized by using FT-IR, PXRD, TGA, EDX, and SEM analyses. This catalyst showed high activity in the green production of pyrazolo[b] phthalazine dione derivatives under ultrasonic conditions. The designed catalyst was effectively recovered and successfully reused at least eight times without significant loss in its efficiency.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Kargar, S; Elhamifar, D; Zarnegaryan, A or concate me.. SDS of cas: 99-61-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Bioactive naphthoquinone and anthrone derivatives from endophytic Micromonospora sp. NEAU-gq13 WOS:000500123000002 published article about FUNGI in [Li, Jian-Song; Zhang, Hui; Qi, Huan; Wang, Ji-Dong] Zhejiang Hisun Pharmaceut Co Ltd, Zhejiang Key Lab Antifungal Drugs, Taizhou 318000, Peoples R China; [Xiang, Wen-Sheng] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Heilongjiang, Peoples R China in 2019, Cited 16. Recommanded Product: 90-44-8. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Two new naphthalenone derivatives, 5-hydroxy-4-oxo-2-(2-oxopropyl)-1,2,3,4-tetrahydronaphthalen-1-yl acetate (1) and 5-hydroxy-2-(2-hydroxypropyl)naphthalene-1,4-dione (2), together with two new anthrone derivatives, (S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3) and 4,5-dihydroxy-2-methyl-9H-xanthen-9-one (4), were isolated from the fermentation broth of endophytic Micromonospora sp. NEAU-gq13. Their structures were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS analysis. Compounds 2 and 3 exhibited strong cytotoxic activity against human central nervous system cancer (SF-268) with the IC50 values of 3.04 and 5.66 mu g/ml, respectively. Moreover, compound 2 also displayed potent activity against human liver cancer (HepG2) with an IC50 value of 1.01 mu g/ml.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Athira, M; Shanmugam, P in [Athira, Mohanakumaran; Shanmugam, Ponnusamy] CSIR Cent Leath Res Inst CLRI, Organ & Bioorgan Chem Div, Chennai 600020, Tamil Nadu, India published Synthesis of Functionalized 9-Substituted Fluorene Derivatives via Boron Trifluoride Catalysed Reaction of Coplanar 9-(Phenylethynyl)-9H-fluoren-9-ols, Aryl Aminoamides and N-Bromosuccinimide in 2021, Cited 32. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A boron trifluoride catalysed reaction of coplanar 9-(phenyl-ethynyl)-9 H-fluoren-9-ols with various 2-aminobenzamides affords a number of highly functionalized, conjugated (Z)-2-((2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino) benzamides in excellent yield. The reaction in the presence of N-bromosuccinimide affords (E)-5-bromo-2-((2-bromo-2-(9 H-fluoren-9-ylidene)-1-phenylethylidene)amino)benz-amides in very good yields. The scope of the reaction is demonstrated by selecting N-aryl substituted 2-aminobenzamides and aminosulfonamides as reaction partners. The structures of representative compounds were established by single-crystal XRD analysis. Based on the structure of the products, a plausible mechanism via formation of allene carbocation intermediates is proposed.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Athira, M; Shanmugam, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of Anthrone. Recently I am researching about AROMATIC POLYAMIDES; POLYIMIDES; ETHER; UNIT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21564005, 51663011]; Research Program of Jiangxi Science and Technology Department [20192BBE50049]; Ground Project for Science and Technology of Jiangxi Universities [KJLD14022]; Research Program of Jiangxi Province Department of Education [GJJ14236]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Zhou, YF; Huang, ZZ; Mao, XC; Song, C. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

A new aromatic diamine, 10,10-bis [4-(4-amino-2-pyridinoxy)phenyl]-9(10H)-anthracenone (BAPPA) was synthesized from anthrone as the starting material, and the corresponding pyridine- and anthrone-containing poly(ether amide)s (PEAs) were prepared from BAPPA with various aromatic diacid chlorides via a low-temperature solution polycondensation. The resulting PEAs having number-average molecular weights (M-n) of 29,500-33,400 g/mol with the polydispersity index ranged from 1.75 to 1.84, were all amorphous, and displayed excellent thermal stability with the glass transition temperatures of 263-355 degrees C, the temperatures of 415-441 degrees C at 5% weight loss and the higher than 50% residues at 800 degrees C in nitrogen. These new PEAs were soluble in polar solvents such as N-methyl-2-pyrrolidone, N,N-dimethylacetamide and pyridine, even almost in tetrahydrofuran at room temperature and could form transparent, strong and flexible films with tensile strengths of 84-97 MPa, tensile moduli of 2.1-3.2 GPa and elongations at break of 4-13%. Also, the present PEAs exhibited high optical transparence with the UV cutoff wavelength in the 342-362 nm range, and 83-90% transmittance at 500 nm. These results indicated the introduction of anthrone and pyridine groups into the backbone could improve the solubility and transparence of polyamides.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Chromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study WOS:000470939200050 published article about ASYMMETRIC TRANSFER HYDROGENATION; CROSS-COUPLING REACTIONS; ENANTIOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; HOMOGENEOUS HYDROGENATION; GRIGNARD-REAGENTS; IRON; COMPLEXES; ARENES; ARYL in [Han, Bo; Zeng, Xiaoming] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Shaanxi, Peoples R China; [Zeng, Xiaoming] Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China; [Ma, Pengchen; Chen, Hui] Chinese Acad Sci, BNLMS, CAS Key Lab Photochem, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China; [Han, Bo] Yanan Univ, Coll Chem & Chem Engn, Shaanxi Key Lab Chem React Engn, Yanan 716000, Peoples R China; [Cong, Xuefeng] Northeast Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China in 2019, Cited 93. HPLC of Formula: C14H10O. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Polycyclic aromatic hydrocarbons are difficult substrates for hydrogenation because of the thermodynamic stability caused by aromaticity. We report here the first chromium- and cobalt-catalyzed, regiocontrolled hydrogenation of polycyclic aromatic hydrocarbons at ambient temperature. These reactions were promoted by low-cost chromium or cobalt salts combined with diimino/carbene ligand and methylmagnesium bromide and are characterized by high regioselectivity and expanded substrate scope that includes tetracene, tetraphene, pentacene, and perylene, which have rarely been reduced. The approach provides a cost-effective catalytic protocol for hydrogenation, is scalable, and can be utilized in the synthesis of tetrabromo- and carboxyl-substituted motifs through functionalization of the hydrogenation product. The systematic theoretical mechanistic modelings suggest that low-valent Cr and Co monohydride species, most likely from zerovalent transition metals, are capable of mediating these hydrogenations of fused PAHs.

HPLC of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Han, B; Ma, PC; Cong, XF; Chen, H; Zeng, XM or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem