An article Biotransformation of Benzoate to 2,4,6-Trihydroxybenzophenone by Engineered Escherichia coli WOS:000650680700001 published article about INHIBITORY NATURAL-PRODUCTS; BENZOPHENONE SYNTHASE; RHODOPSEUDOMONAS-PALUSTRIS; PRENYLATED BENZOPHENONES; ANTIBACTERIAL ACTIVITY; UNNATURAL FLAVONOIDS; MICROBIAL-PRODUCTION; CHALCONE SYNTHASE; BIOSYNTHESIS; XANTHONES in [Klamrak, Anuwatchakij; Nualkaew, Natsajee] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand; [Nabnueangsap, Jaran] Mahidol Univ, Salaya Cent Instrument Facil RSPG, Salaya, Nakhon Pathom 73170, Thailand in 2021.0, Cited 79.0. Category: thiomorpholine. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9
The synthesis of natural products by E. coli is a challenging alternative method of environmentally friendly minimization of hazardous waste. Here, we establish a recombinant E. coli capable of transforming sodium benzoate into 2,4,6-trihydroxybenzophenone (2,4,6-TriHB), the intermediate of benzophenones and xanthones derivatives, based on the coexpression of benzoate-CoA ligase from Rhodopseudomonas palustris (BadA) and benzophenone synthase from Garcinia mangostana (GmBPS). It was found that the engineered E. coli accepted benzoate as the leading substrate for the formation of benzoyl CoA by the function of BadA and subsequently condensed, with the endogenous malonyl CoA by the catalytic function of BPS, into 2,4,6-TriHB. This metabolite was excreted into the culture medium and was detected by the high-resolution LC-ESI-QTOF-MS/MS. The structure was elucidated by in silico tools: Sirius 4.5 combined with CSI FingerID web service. The results suggested the potential of the new artificial pathway in E. coli to successfully catalyze the transformation of sodium benzoate into 2,4,6-TriHB. This system will lead to further syntheses of other benzophenone derivatives via the addition of various genes to catalyze for functional groups.
Category: thiomorpholine. About Benzophenone, If you have any questions, you can contact Klamrak, A; Nabnueangsap, J; Nualkaew, N or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem