Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Theodosis-Nobelos, Panagiotis, once mentioned the application of 90-44-8, Name is Anthrone, molecular formula is C14H10O, molecular weight is 194.2286, MDL number is MFCD00001187, category is thiomorpholine. Now introduce a scientific discovery about this category, Application In Synthesis of Anthrone.
Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), alpha-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60-92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemic rats. The most potent compound was the indomethacin derivative, which decreased total cholesterol, triglycerides and LDL cholesterol by 73%, 80% and 83%, respectively. They reduced acute inflammation equally or more than most parent acids. Hence, it could be concluded that amides of common NSAIDs with thiomorpholine acquire considerable hypolipidemic potency, while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. (C) 2015 Elsevier Ltd. All rights reserved.
I am very proud of our efforts over the past few months and hope to 90-44-8 help many people in the next few years. Application In Synthesis of Anthrone.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem