The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Soliman, Beatrice, once mentioned the application of 115-86-6, Name is Triphenyl phosphate, molecular formula is C18H15O4P, molecular weight is 326.2831, MDL number is MFCD00003031, category is thiomorpholine. Now introduce a scientific discovery about this category, Product Details of 115-86-6.
Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H-4 receptor (hH(4)R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of replacing the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C-3-C-5) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand-binding assays exhibited only very weak activity at the hH(1)R and hH(3)R, while nearly all compounds were inactive at the hH(2)R and hH(4)R. In the case of piperidine-containing compounds, moderate affinities at the hH(3)R over the single-digit micromolar range were detected.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.If you are interested in 115-86-6, you can contact me at any time and look forward to more communication. Product Details of 115-86-6.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem